Data epidemiological link to melanoma to intense sun exposure during childhood, and provides support for the role of the grape. While there is agreement that the UV radiation is the cause however, length accurate wave and committed mechanisms is not clear. Setlow and collaborators (1993) demonstrated the induction of melanoma in a model of fish Xiphophorus by UVA, UVB and visible blue wavelengths; Law (1997) showed equal effectiveness of the UVA and UVB in inducing hyperplasia in the Mono-delphis melanocytic domestic and Noonan et al. Contact information is here: Kyle Dropp dartmouth. (2001, 2003) using wavelengths combined UVB and UVA, recently demonstrated the induction of melanoma in a transgenic model of a newborn mouse. Berking and collaborators (2001) demonstrated that the UVB in combination with basic fibroblast growth factor can transform human melanocytes. The role of the grape in human melanoma is still not conclusive (Wang et al., 2001) while the UVB are believed that they interact directly with DNA to start significant mutations of basal and squamous, carcinomatosas cells wavelength UVA (320-400 nm) believed that they interact indirectly by inducing the production of radical free.
Free radicals can indirectly damage DNA and protein damage, which contributes to premature aging or photoaging. The production induced by grape of p53 and damage DNA, genomic instability, and immunosuppression have been shown. Despite the extensive use of sunscreens during the past 2 decades, the incidence of skin cancer is on the rise and the role of sunscreens in skin cancer protection is controversial. The use of sunscreens demonstrated to reduce the formation of Actinic queratocitos, which are linked to squamous cell carcinoma. Animal models have demonstrated that sunscreens reduce the incidence of basal and squamous, tumor cells that are in relation with UVB; However there are some studies that suggest that the use of filters plots is associated with an increased risk of melanoma. This may reflect an inadequate application of sunscreen; combined lack of durability of the application, lack or insufficiency of UVA filters in sunscreens preparations this with a long bath of Sun; the instability of sunscreens photo causes a reduced protection; or reactive free radical production or mutagens into the cream.